GENERAL CHARACTERISTICS OF SCIENTIFIC ORGANIZATION
Scientific organization infrastructure
Report on the main reference group 25 Fundamental medicine
Report generation date: 05/19/2017
1. Profile of activity according to the list approved by the minutes of the meeting of the Interdepartmental Commission for the Evaluation of the Effectiveness of Scientific Organizations Performing Research, Development and Technological Work for Civilian Design dated January 19, 2016 № DL-2 / 14pr.
"The generation of knowledge." The organization is mainly focused on obtaining new knowledge. It is characterized by a high level of publication activity, incl. in the world's leading magazines. Research and development related to obtaining applied results and their practical application, occupy a small part, which is reflected in relatively low indicators for the creation of IARs and small amounts of income from the provision of scientific and technical services. (1)
2. Information on the structural units of the scientific organization
1. Laboratory of Immunology and Cell Biology. Studies are being conducted to study the immune status of monkeys in normal and pathological conditions in a comparative aspect with the human immune system, cultures of mesenchymal stem cells are created and their properties are studied. A cryobank of lymphoid and mesenchymal stem cells is supported.
2. Laboratory of Infectious Pathology. Studies are conducted to investigate normal, conditionally pathogenic and pathogenic microflora of monkeys (bacteria, parasitic invasions).
3. Laboratory of Infectious Virology. Investigations of infectious viruses of primates are carried out.
4. Zootechnical laboratory. Studies are conducted on the large-scale maintenance and breeding of laboratory primates and on zoopsychology.
5. Laboratory of endocrinology. Studies are being conducted to invstigate the endocrine system of primates, and the effect of stress on the endocrine system.
6. Laboratory of pathological anatomy. Anatomy studies are conducted on healthy primates as well as on individuals with pathological changes.
7. Laboratory of Molecular Biology. Molecular and biological studies are directed mainly on the infectious pathology of primates.
8. Zootechnical department. The Institute's nursery contains about 5,000 primates of 20 species.
9. Clinical and veterinary department. The department carries out the examination and treatment of primates.
3. Scientific Research infrastructure
1. Continuous cytofluorometer ERICS XL 4 COLOR (Beckman Coulter, USA).
2. Instrument for real-time polymerase chain reaction Rotor-Gene (Qiagen, Australia)
3. Amplifier for real-time PCR iCycler iQ (Bio-Rad, Sweden).
4. Ultracentrifuge, model OPTIMA L-80XP (Beckman Coulter, USA) in biosafety
performance
4. The total area of experimental fields assigned to the institution. It is filled in by organizations that have chosen reference group No. 29 “Plant technology”
Information not provided
5. The number of long-term stationary experiments conducted by the organization for the period from 2013 to 2015. It is filled in by organizations that have chosen reference group No. 29 “Plant growing technologies”
Information not provided
6. Indicators of the activities of organizations for the storage and enhancement of the subject base of scientific research
A collection of species of higher primates.
The short register as of the end of 2015:
1. Rhesus monkeys (Macaca mulatta) - 1865 individuals;
2. Pig-tailed macaques (Macaca nemestrina) - 97ind. ;
3. Crab-eating macaques (Macaca fascicularis) - 1279 individuals;
4. Stump-tailed macaques (Macaca arctoides) - 7 ind.;
5. Assam macaques (Macaca assamensis) - 14 ind.;
6. Celebes macaque (Macaca nigra) - 1 ;
7. Barbary ape (Macaca sylvana) - 6;
8. Lion-tailed macaque (Macaca silenus)-1;
9. Hamadryas baboon (Papio hamadryas)- 843 ind;
10.Anubis baboons - 336 ind;
11. Green monkeys (Chlorocebus aethiops) - 187 ind;
12. Mona monkey (Cercopithecus mona) - 1 ind;
13. Allen’s monkey (Cercopithecus nigroviridus) - 3 ind;
14. White-nosed guenons (Cercopithecus nictitans) - 2 ind;
15. Blue Monkeys (Cercopithecus mitis) - 4 ind;
16. Patas (Erythrocebus patas – 6 ind;
17. Mangobei black (Cercocebus nigra)1 ind.
18. Brown capuchins (Cebus paella) - 16 ind;
19. White- throated capuchins (Cebus capucinus) - 6 ind;
20. Squirrel monkeys (Saimiri sciureus) - 3 ind;
7. Importance of the organization’s activities for the socio-economic development of the relevant region
The Institute and its nursery are objects of scientific tourism in the resort city of Sochi and are included in the list of the most significant objects of the city. On the basis of the Institute there is an exhibition area where tours are guided. Every year more than 25 thousand people visit the primate nursery.
8. Strategic development of a scientific organization
It is planned to create on the basis of the Institute an interdisciplinary research center with a laboratory of preclinical trials of the GLP standards, in which research institutions of various departmental subordination and forms of ownership would conduct medical and biological research on laboratory primates.
Research Institute of Medical Primatology in long-term partnership with organizations:
1. Federal State Budgetary Institution “Federal Research Center for Epidemiology and Microbiology named after honorary academician N.F Gamaleya” of the Ministry of Health of Russia, Moscow.
2. "48 Central Research Institute" Ministry of Defense of Russia, Kirov
3. Virological center "48th Central Research Institute" Ministry of Defense of Russia, Sergiev Posad.
3. Russian Federal Nuclear Center - All-Russian Research Institute of Experimental Physics - RFNC-VNIIEF, Sarov
4. FSBUN SSC “Institute of Biomedical Problems” of the Russian Academy of Sciences, Moscow
5. ZAO Biocad, Petrovo Village, Krasnogorsky District, Moscow Region
6. JSC "Generium", pos. Volginsky, Vladimir region.
7. Federal State Autonomous Educational Institution of Higher Education "Kazan (Volga Region) Federal University", Kazan
8. GBUZ "Research Institute - Regional Clinical Hospital №1
behalf of Professor S.V. Ochapovski ", Krasnodar
9. Federal Research Center for Research and Development of Immunobiological Preparations named after MP Chumakov, Russian Academy of Sciences, Moscow
Integration into the global scientific community
9. Participation in large international consortia (for example - CERN, JINR, FAIR, DESY, ISS and others) in the period from 2013 to 2015
Information not provided
10. Inclusion of field experiences of the organization in the Russian and international research networks. Is filled by organizations that have chosen reference group number 29 "Plant Technology"
Information not provided
11. Availability of foreign grants, international research programs or projects for the period from 2013 to 2015
The "Agreement on cooperation in basic biomedical research" was concluded with the University Clinic for Cardiothoracic Transplantation and Vascular Surgery of the Hannover Medical School for the period 2013-2018. In 2013-2015, studies were carried out on subcutaneous xenotransplantation of the valves of the heart of a pig to hamadryas baboons . Encouraging results have been obtained, research is ongoing.
SCIENTIFIC POTENTIAL OF THE ORGANIZATION
The most significant results of basic research
12. Scientific areas of research conducted by the organization, and the most significant results obtained in the period from 2013 to 2015
Number 67.Study of the mechanisms of psycho-emotional stress and resistance to it.
Studies have been conducted to investigate the nature of age related and individual characteristics of the regulation of the hypothalamic-pituitary adrenal system (GGAS) according to the mechanism of negative feedback. 10 young (6-9 years) and 10 old (20-29 years) animals of different psycho-physiological type (standard, control - SB; depressive-like and restless - DAB) after their adaptation to the living conditions in individual metabolic cells were administered intramuscularly dexamethasone in a dose 0.5 mg / kg at 22.00 h - the period of minimal activity of GGAS and, as expected, the greatest sensitivity of GGAS to stimuli). A similar pattern of corticosteroid concentrations was found in young and old animals, regardless of their belonging to a psychophysiological type prior to drug administration, 12 and 18 hours later with maximum inhibition after 18 hours. Return to the original level of functioning of GGAS was age-dependent in its nature: in young animals, return to the initial level of functioning occurred after 36 hours, while in old animals at that time suppression of corticosteroid secretion persisted (p <0.001).
1. Individual differences in stress responsiveness of the hypothalamic- pituitary-adrenal axis and its vasopressinergic regulation in old monkeys.
ND Goncharova, VY Marenin, TE Oganyan. Journal of Behavioral and Brain Science 5 (7), 280-294, 2015
2. Age-specific and individual features of vasopressinergic regulation of the Hypothalamic-pituitary-Adrenal system in Primates
ND Goncharova, TE Oganyan, VY Marenin, AA Vengerin. Bulletin of experimental biology and medicine 158 (6), 804-806, 2015
3. Correction of impaired glucose tolerance using tetrapeptide pancragen in old female rhesus monkeys
ND Goncharova, LG Ivanova, TE Oganyan, AA Vengerin, VK Khavinson. Adv. geront. 28 (3), 579-585, 2015
4. AGE-related and individual characteristics of vasopressinergic regulation of the hypothalamo-pituitary adrenal system in primates
Goncharova N.D., Oganyan T.E., Marenin V.Yu., Vengerin A.A. Bulletin of experimental biology and medicine. 2014. T. 158. No. 12. P. 773-776.
5. Age-related disturbances of the hypothalamo-pituitary adrenal system: experimental research on primates.
Goncharova N.D. Successes of gerontology. 2014. Vol. 27. No. 2. P. 269-274.
№ 75. Development of standardized biomodels in laboratory animals.
Eighteen biochemical parameters of blood sera of males of cynomolgus monkeys of different rank generally correspond to the values characteristic for macaques. For all the analyzed serum biochemical parameters, there are no significant differences between high-ranking and low-ranking animals . It shows a comparable level of clinical state of different rank monkeys.
High-ranking individuals demonstrate a high level of ability to solve tests on spatial orientation, an average level of ability to learn, and, on average, a low level of research activity. At the same time, individual differences are most pronounced when performing tests for exploratory activity or tests related to spatial orientation and ability to learning high-ranking animals could be divided into fairly homogeneous groups. Individuals of the low-ranking group show very ambiguous results. In animals of this category individual differences are more pronounced.
The aggressiveness of males is closely related to their dominance. The direct form of implementation of the hierarchical claims of male rhesus macaques is a demonstration of aggressiveness. The aggressiveness of males is not a quality that determines their anxiety. However, high anxiety, with a high probability, is associated with high aggressiveness. By their temper, males of rhesus monkeys can be divided into two categories: males with an active temper and males with a passive temper. Males with an active temper have a significantly higher motor activity, aggressiveness, and lower sociability and depression. Males with a passive temper are divided into two subcategories: passive confident (high-ranking males) and passive insecure (low-ranking).
1.THE ABILITY OF ADOLESCENT HAMADRYAS BABOONS (PAPIO HAMADRYAS) TO SOLVE A MODIFIED PIAGET A-NOT-B ERROR TEST
Anikaev A.E., Chalyan V.G., Meishvili N.V. Neuroscience and Behavioral Physiology. 2015. 2. RESEARCH OF ABILITIES OF HAMADRYAS BABOONS (PAPIO HAMADRYAS) TO SOLVING TASKS ON SUBJECT MANIPULATION
Anikaev A.E., Chalyan V.G., Meishvili N.V. Bulletin of experimental biology and medicine. 2015. V. 159. № 1. S. 95-97.
3. RELATIONS BETWEEN MALES AND INFANTS WITH IN MACQUES AND BABOONS (COMPARATIVE STUDY)
Y. Lipina, N.V. Meishvili, V.G. Chalyan Bulletin of Moscow University. Series 23: Anthropology. 2014. № 2. S. 99-108.
4. ABILITY OF ADOLESCENT HAMADRYAS BABOONS (PAPIO HAMADRYAS) TO SOLVING THE MODIFIED TASK OF THE PAYAGE “A-NOT-B ERROR”
Anikaev A.E., Chalyan V.G., Meishvili N.V. Russian physiological journal named after I.M. Sechenov. 2014. T. 100. No. 4. P. 394-405.
Number 81. Development of new cellular technologies.
The experimental myocardial infarction was reproduced on hamadryas baboons by bandaging at the border of the middle and upper third of the coronary and anterior descending artery. Myocardial infarction was confirmed by ECG and biochemical tests. Introduction of allogenic mesenchymal stem cells (MSCs) at the rate of 2 million / kg of weight during the first day of the infusion resulted in 3 years of observation of vascularization and capillarization of the myocardial infarction zone, detected in histological sections, unlike the control animals (not received MSC), in which the growth of coarse fibrous connective tissue was determined in the infarction area.
The bank of cryconserved cells was replenished with a new depositor — a culture of human cardiomyocytes (CSK-O), obtained as a result of the differentiation of human stem cells after exposure to the 5-azacytidine differentiating agent.
For therapeutic purposes, stem cell culture fluid (QOL) was used. Skin lesions, deep necrosis on the surface of the body treated with QOL led to wound cleansing, the formation of granulations and, ultimately, to healing with slightly noticeable depigmentation sites that occurred much faster than with the use of classical medical preparations.
1. Cellular immunity standard values in Macaca fascicularis. Ignatova IE, Agrba VZ, Karal- Ogly DD.
Bull Exp Biol Med. 2014 Jun; 157 (2): 265-7. doi: 10.1007 / s10517-014-2541-x. ,Epub 2014
Jun 24.
2. Physiological parameters of Macaca fascicularis immunized with anti-rubella vaccine with germanium-based adjuvants.
Karal-Ogly DD, Agrba VZ, Lavrent'eva IN, Ambrosov IV, Matelo SK, Chuguev YP, Gvaramiya IA, Gvozdik TE, Mukhametzyanova EI.
Bull Exp Biol Med. 2014 May; 157 (1): 81-4. doi: 10.1007 / s10517-014-2497-x. Epub 2014
Jun 10.
3. RESEARCH OF THE BIOLOGICAL SAFETY OF THE INCRETE OF VITALY IMPORTANT PARENCHIMATOUS ORGANS OBTAINED AS A RESULT OF ISOLATED EXTRACORPORAL PERFUSION OF XENOGENIC BIO MATERIAL. Agrba V.Z., Lubyako A.A., Araviashvili D.E., Coral-Ogly D.D., Chuguev Yu.P., Ignatova I.E., Sergeeva N.V., Gvaramiya I.A., Rusia A.G., Budanov R.V. Bioprotection and biosafety. 2013. Vol. 5. No. 1 (14). Pp. 44-58.
4. TRANSPLANTATION OF MESENCHEMAL STEM CELLS OF PRIMATES TO MONKEYS WITH EXPERIMENTALLY INDUCED MI-CARD INFARCT
Agrba V.Z., Porkhanov V.A., Karal-ogly D.D., Leontyuk A.V., Kovalenko A.L., Sholin I.Yu., Gvozdi
4. TRANSPLANTATION OF MESENCHEMAL STEM CELLS OF PRIMATS TO MONKEYS WITH EXPERIMENTALLY INDUCED MI-CARD INFARCT
Agrba V.Z., Porkhanov V.A., Karal-ogly D.D., Leontyuk A.V., Kovalenko A.L., Sholin I.Yu., Gvozdik T.E., Ignatova I.E., Agumava A.A., Chuguev Yu.P., Gvaramiya I.A., Lapin B.A. Cell technology in biology and medicine. 2015. No. 4. P. 286-288.
№ 119. Molecular epidemiology, ecology of infectious agents
During the massive outbreak of infectious myocarditis, among the hamadryas baboons the Mengo-like virus strain 3761 UTI (family Picornaviridae, genus Cardiovirus) was isolated from a dead animal. A full-length genome of the virus was identified. A real-time PCR test system was developed to detect RNA viruses of the genus Cardiovirus.
194 cultures of S.aureus, 6 - S.epidermidis, 3- S.intermedius, 1 - S.simulans, 1- S.haemolyticus, 1 - S.sciuri were isolated from monkeys. Oxacillin-resistant strains of staphylococci were shown to be more common in monkeys than in humans (20.7% and 5%, respectively). Vancomicin-resistant S.aureus strains isolated from monkeys were found in 6.3% of cases, while this antibiotic-resistant isolates of Staphylococcus aureus from humans were not noted. All cultures of S.aureus exhibit high sensitivity to antimicrobial agents of various groups. Based on the group of the group of strains of lotus staphylococcus, which included, first of all, isolates from pneumonia, intestinal infection, pus in various biomaterials, the structural polymorphism of the variable region of the coagulase gene was studied by PCR-RFLP. The vast majority of isolates from monkeys, , belonged to 2 groups of the coagulase gene - the 4th and 12th according to the type of restriction.
Hepatitis A virus (HAV) has been identified, which caused HAV infection in green monkeys imported from natural habitats (Tanzania). In monkeys all specific laboratory markers characteristic of hepatitis A were detected: anti-HAV IgM, anti-HAV IgG, Ag HAV, and HAV RNA. The cause of the infection was the HAV V genotype belonging to strains of monkey origin which was confirmed by sequencing and phylogenetic analysis.
1. Lapin BA, Yakovleva LA. Spontaneous and experimental malignancies in non-human primates. J Med Primatol. 2014 Apr; 43 (2): 100-10. doi: 10.1111 / jmp.12098. Epub 2014 Jan 7.
2. Historical Outbreaks of Simon Hemorrhagic Fever in Cavity Macaques Were Caused by Distinct Arteriviruses.
Lauck M, Alkhovsky SV, Bào Y, Bailey AL, Shevtsova ZV, Shchetinin AM, Vishnevskaya TV, Lackemeyer MG, Postnikova E, Mazur S, Wada J, Radoshitzky SR, Friedrich TC, Lapin BA, Deriabin PG, Jahrling PB, Goldberg TL , O'Connor DH, Kuhn JH. J Virol. 2015 Aug; 89 (15): 8082-7. doi: 10.1128 / JVI.01046-15.
3. STUDY OF A POSSIBLE ROLE OF CYTOMEGALOVIRUS INFECTION IN THE DEATH AND EARLY NEONATAL MORTALITY OF INFANTS OF ADLER COLONY. Shamsutdinova O.A., Agumava A.A., Chikobava M.G., Vyshemirsky O.I.
Bulletin of experimental biology and medicine. 2015. V. 160. № 7. S. 101-103.
4. SENSITIVITY TO ANTIBACTERIAL DRUGS
STAPHYLOCOCCUS AUREUS FROM MONKEYS. Kalashnikov V.A.
Bulletin of veterinary medicine. 2015. № 4 (75). Pp. 35-39.
5. RF patent “Method for PCR analysis of a biological object, a device for its implementation and composition included in the device” No. RU 2012140241 dated 03/27/2014
13. Protected dissertations prepared for the period from 2013 to 2015 based on field experimental work of the institution. It is filled in by organizations that have chosen reference group No. 29 “Plant growing technologies”.
Information not provided
14. The list of the most significant publications and monographs prepared
employees of the scientific organization for the period from 2013 to 2015
Publications.
1. An enzootic outbreak of disease associated with pathogenic E. coli in Adler monkey colony.
Lapin BA, Yakovleva LA, Dzhikidze EK, Gvozdik TE, Agumava AA, Stasilevich ZK, Danilova IG.
J Med Primatol. 2015 Dec; 44 (6): 355-63. doi: 10.1111 / jmp.12184. Epub 2015 Jul 27. Impact factor 0.93, Scientific Citation Systems Web of Sci, PubMed
2. Historical Outbreaks of Simon Hemorrhagic Fever in Cavity Macaques Were Caused by Distinct Arteriviruses.
Lauck M, Alkhovsky SV, Bào Y, Bailey AL, Shevtsova ZV, Shchetinin AM, Vishnevskaya TV, Lackemeyer MG, Postnikova E, Mazur S, Wada J, Radoshitzky SR, Friedrich TC, Lapin BA, Deriabin PG, Jahrling PB, Goldberg TL , O'Connor DH, Kuhn JH.
J Virol. 2015 Aug; 89 (15): 8082-7. doi: 10.1128 / JVI.01046-15. Epub 2015 May 13.
Impact factor 4,606, Web of Sci, Scientific Citation Systems, PubMed
3. Spontaneous and experimental malignancies in non-human primates. Lapin BA, Yakovleva LA.
J Med Primatol. 2014 Apr; 43 (2): 100-10. doi: 10.1111 / jmp.12098. Epub 2014 Jan 7. Review. Impact factor 0.93, Scientific Citation Systems Web of Sci, PubMed
4. Cellular immunity standard values in Macaca fascicularis. Ignatova IE, Agrba VZ, Karal-Ogly DD.
Bull Exp Biol Med. 2014 Jun; 157 (2): 265-7. doi: 10.1007 / s10517-014-2541-x. Epub 2014
5. Age-specific and individual features of vasopressinergic regulation of the hypothalamic-pituitary-adrenal system in primates.
Goncharova ND, Oganyan TE, Marenin VY, Vengerin AA.
Bull Exp Biol Med. 2015 Apr; 158 (6): 804-6. doi: 10.1007 / s10517-015-2866-0. Epub 2015
Apr 21.
Impact factor 0.448, Web of Sci, Scientific Citation Systems, PubMed
6. Study of Hamadryas Baboons (Papio Hamadryas) Ability to Solve Object Manipulation Tasks.
Anikaev AE, Chalyan VG, Meishvili NV.
Bull Exp Biol Med. 2015 May; 159 (1): 85-6. doi: 10.1007 / s10517-015-2896-7. Epub 2015
Jun 3.
Impact factor 0.448, Web of Sci, Scientific Citation Systems, PubMed
7. Role of anaerobic bacteria in simian enteric diseases. Stasilevich ZK, Dzhikidze EK, Kalashnikova VA, Sultanova OA.
Bull Exp Biol Med. 2013 Dec; 156 (2): 248-51. DOI: 10.1007 / s10517-013-2323-x
Impact factor 0.448, Web of Sci, Scientific Citation Systems, Pub Med
8. Potential Contribution of the Prenatal and Early Neonatal Mortality of Monkeys in the Adler Breeding Center.
Shamsutdinova OA, Agumava AA, Chikobava MG, Vyshemirsky OI.
Bull Exp Biol Med. 2015 Nov; 160 (1): 88-90. doi: 10.1007 / s10517-015-3105-4. Epub 2015
Nov 25.
Impact factor 0.448, Web of Sci, Scientific Citation Systems, PubMed
9. Analysis of the patient-reported outcomes from the LUME-Lung 1 trial: a randomized, double-blind, placebo-controlled study.
Novello S, Kaiser R, Mellemgaard A, Douillard JY, Orlov S, Krzakowski M, Von Pawel J, Gottfried M, Bondarenko I, Liao M, Barrueco J, Gaschler-Markefski B, Griebsch I, Palmer M, Reck M; LUME-Lung 1 Study Group ..
Eur J Cancer. 2015 Feb; 51 (3): 317-26. doi: 10.1016 / j.ejca.2014.11.015. Epub 2014 Dec 17.
Impact factor 6,163, Web of Sci, Scientific Citation Systems, PubMed
10. Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomized, phase 3 trials.
Yang JC, Wu YL, Schuler M, Sebastian M, Popat S, Yamamoto N, Zhou C, Hu CP, O'Byrne K, Feng J, Lu S, Huang Y, Geater SL, Lee KY, Tsai CM, Gorbunova V, Hirsh V, Bennoun J, Orlov S, Mok T, Boyer M, Su WC, Lee KH, Kato T, Massey D, Shahidi M, Zazulina V, Sequist LV.
Lancet Oncol. 2015 Feb; 16 (2): 141-51. doi: 10.1016 / S1470-2045 (14) 71173-8. Epub 2015
Jan 12.
Impact factor 26,509, Web of Sci Scientific Citation Systems, PubMed Monographs.
1. Vladimir S. Saakov, Alexander I. Krivchenko, Eugene Rozengardt, Irina G. Danilova. "Derivative Spectrophotometry and PAM-Fluorescence in Corporative Biochemistry". Springer International Publishing AG Switzerland, 2015, 611 p. ISBN 978-3-319-11595-5, ISBN 978-3- 319-11596-2 (eBook), DOI 10.1007 / 978-3-319-11596-2
15. Grants for basic research implemented with the support of the Russian Foundation for Basic Research, the Russian Humanitarian Scientific Foundation, the Russian Scientific Foundation and others
1. RFBR project No. 15-04-07896-a “Development of biomarkers of increased vulnerability to stress and accelerated aging based on studying the characteristics of vasopressinergic regulation of the stress-reactivity of GGAS in laboratory primates differing in the type of adaptive behavior”.
Duration 2015-2017 General financing 1.600.000,00 rub.
2. RFBR project No. 15-04-05283-a "Study of the ability to learning in lower monkeys of different age group ."
Duration 2015-2017 Total financing 1.425.000,00 rub.
16. Grants implemented on the basis of the organization's field experience with the support of Russian and International scientific foundations. It is filled in by organizations that have chosen reference group No. 29 “Crop technology”.
Information not provided
INNOVATIVE POTENTIAL OF SCIENTIFIC ORGANIZATION
The most significant results of exploratory and applied research
17. Exploratory and applied projects implemented within the framework of federal targeted programs, as well as with the support of development funds from 2013 to 2015
Information not provided
Innovative potential of a scientific organization
18. Availability of technological infrastructure for applied research.
Information not provided
19. The list of the most significant developments of the organization, which were introduced for the period from 2013 to 2015
Information not provided
EXPERT AND CONTRACTING ACTIVITIES OF THE ORGANIZATION
Expert activities of scientific organizations
20. Preparation of normative-technical documents of international, interstate and national importance, including standards, norms, rules, technical regulations and other regulatory documents approved by federal executive bodies, international and intergovernmental bodies
Information not provided
Doing research and services for other organizations
21. List of the most significant research, developmental and technological works and services performed under contracts for the period from 2013 to 2015
1. “Work on the preparation of primates for subsequent preclinical studies of promising vaccines against particularly dangerous viral diseases”. Customer FGBU "FNITSEM them. N.F. Gamalei "of the Ministry of Health of Russia, 2015.
2. "Conducting a preclinical study to investigate a comparative toxicity of the Rituximab bioassay drug (Mabsiens SA) with repeated administration in comparison with the reference drug Mabthera (F. Hoffmann-La Rosh) and the intact group" Customer Nanolek LLC , year 2014.
3. " Study of chronic toxicity and pharmacokinetics of the drug CON-2302 in monkeys", the customer of CJSC Research Institute of Chemical Diversity, 2014.
4. "Preclinical study of toxicity and pharmacokinetics with a single intravenous administration of BCD-100 on cynomolgus monkeys (Macaca fascicularis)", the customer of ZAO "Biocad". 2015
5. “Preclinical toxicity study with repeated intravenous administration of BCD-100 for 13 weeks followed by a 13-week recovery period on cynomolgus monkeys (Macaca fascicularis), performed in accordance with the GLP Good Laboratory Practice Standard”, the customer is Biocad CJSC. 2015
6. “Comparative toxicity with repeated subcutaneous administration and local irritating action on Javanese macaques (Macaca fascicularis) of Adalimumab (FARMAPARK LLC, Russia) and Humira reference drug (VetterPharma, Germany), customer Biocad CJSC. 2015
7. " Study of anti-inflammatory activity with repeated subcutaneous injection of biospecific monoclonal antibodies against interleukin 17 and tumor necrosis factor alpha BCD-121 to Javanese monkeys (Macaca fascicularis) for 42 days on a collagen-induced arthritis model", customer of Biocad. 2015
8. “ Study of the toxicity and basic pharmacokinetic parameters of the drug BCD-121 in a single subcutaneous injection to Javanese macaques (Macaca fascicularis)” customer Biocad. 2015
Other indicators of a leading position organizations in the relevant scientific direction
(submitted at the request of the organization in free form)
22.Other indicators showing the leading position of the organization of a
relevant scientific direction, and the information that the organization wants to present additionally
The Research Institute of Medical Primatology is a unique research Institution of the Russian Federation. Its colony contains about 5,000 monkeys of 20 species. Thus, the Institute of Medical Primatology is not
only the only primate center of Russia, but also the largest center in Europe.
Laboratory primates are essentially “laboratory counterparts” of man. The results of biomedical and biological experiments obtained on monkeys can be extrapolated to humans in fact without adjustment. The staff of the Institute employs highly qualified specialists who are skillful in large-scale maintenance and breeding of primates, and conducting biomedical experiments on them.
The demand for such experiments in the country is growing, as well as the number
of scientific areas in which the use of laboratory primates is needed.
Scientific organization infrastructure
Report on the main reference group 25 Fundamental medicine
Report generation date: 05/19/2017
1. Profile of activity according to the list approved by the minutes of the meeting of the Interdepartmental Commission for the Evaluation of the Effectiveness of Scientific Organizations Performing Research, Development and Technological Work for Civilian Design dated January 19, 2016 № DL-2 / 14pr.
"The generation of knowledge." The organization is mainly focused on obtaining new knowledge. It is characterized by a high level of publication activity, incl. in the world's leading magazines. Research and development related to obtaining applied results and their practical application, occupy a small part, which is reflected in relatively low indicators for the creation of IARs and small amounts of income from the provision of scientific and technical services. (1)
2. Information on the structural units of the scientific organization
1. Laboratory of Immunology and Cell Biology. Studies are being conducted to study the immune status of monkeys in normal and pathological conditions in a comparative aspect with the human immune system, cultures of mesenchymal stem cells are created and their properties are studied. A cryobank of lymphoid and mesenchymal stem cells is supported.
2. Laboratory of Infectious Pathology. Studies are conducted to investigate normal, conditionally pathogenic and pathogenic microflora of monkeys (bacteria, parasitic invasions).
3. Laboratory of Infectious Virology. Investigations of infectious viruses of primates are carried out.
4. Zootechnical laboratory. Studies are conducted on the large-scale maintenance and breeding of laboratory primates and on zoopsychology.
5. Laboratory of endocrinology. Studies are being conducted to invstigate the endocrine system of primates, and the effect of stress on the endocrine system.
6. Laboratory of pathological anatomy. Anatomy studies are conducted on healthy primates as well as on individuals with pathological changes.
7. Laboratory of Molecular Biology. Molecular and biological studies are directed mainly on the infectious pathology of primates.
8. Zootechnical department. The Institute's nursery contains about 5,000 primates of 20 species.
9. Clinical and veterinary department. The department carries out the examination and treatment of primates.
3. Scientific Research infrastructure
1. Continuous cytofluorometer ERICS XL 4 COLOR (Beckman Coulter, USA).
2. Instrument for real-time polymerase chain reaction Rotor-Gene (Qiagen, Australia)
3. Amplifier for real-time PCR iCycler iQ (Bio-Rad, Sweden).
4. Ultracentrifuge, model OPTIMA L-80XP (Beckman Coulter, USA) in biosafety
performance
4. The total area of experimental fields assigned to the institution. It is filled in by organizations that have chosen reference group No. 29 “Plant technology”
Information not provided
5. The number of long-term stationary experiments conducted by the organization for the period from 2013 to 2015. It is filled in by organizations that have chosen reference group No. 29 “Plant growing technologies”
Information not provided
6. Indicators of the activities of organizations for the storage and enhancement of the subject base of scientific research
A collection of species of higher primates.
The short register as of the end of 2015:
1. Rhesus monkeys (Macaca mulatta) - 1865 individuals;
2. Pig-tailed macaques (Macaca nemestrina) - 97ind. ;
3. Crab-eating macaques (Macaca fascicularis) - 1279 individuals;
4. Stump-tailed macaques (Macaca arctoides) - 7 ind.;
5. Assam macaques (Macaca assamensis) - 14 ind.;
6. Celebes macaque (Macaca nigra) - 1 ;
7. Barbary ape (Macaca sylvana) - 6;
8. Lion-tailed macaque (Macaca silenus)-1;
9. Hamadryas baboon (Papio hamadryas)- 843 ind;
10.Anubis baboons - 336 ind;
11. Green monkeys (Chlorocebus aethiops) - 187 ind;
12. Mona monkey (Cercopithecus mona) - 1 ind;
13. Allen’s monkey (Cercopithecus nigroviridus) - 3 ind;
14. White-nosed guenons (Cercopithecus nictitans) - 2 ind;
15. Blue Monkeys (Cercopithecus mitis) - 4 ind;
16. Patas (Erythrocebus patas – 6 ind;
17. Mangobei black (Cercocebus nigra)1 ind.
18. Brown capuchins (Cebus paella) - 16 ind;
19. White- throated capuchins (Cebus capucinus) - 6 ind;
20. Squirrel monkeys (Saimiri sciureus) - 3 ind;
7. Importance of the organization’s activities for the socio-economic development of the relevant region
The Institute and its nursery are objects of scientific tourism in the resort city of Sochi and are included in the list of the most significant objects of the city. On the basis of the Institute there is an exhibition area where tours are guided. Every year more than 25 thousand people visit the primate nursery.
8. Strategic development of a scientific organization
It is planned to create on the basis of the Institute an interdisciplinary research center with a laboratory of preclinical trials of the GLP standards, in which research institutions of various departmental subordination and forms of ownership would conduct medical and biological research on laboratory primates.
Research Institute of Medical Primatology in long-term partnership with organizations:
1. Federal State Budgetary Institution “Federal Research Center for Epidemiology and Microbiology named after honorary academician N.F Gamaleya” of the Ministry of Health of Russia, Moscow.
2. "48 Central Research Institute" Ministry of Defense of Russia, Kirov
3. Virological center "48th Central Research Institute" Ministry of Defense of Russia, Sergiev Posad.
3. Russian Federal Nuclear Center - All-Russian Research Institute of Experimental Physics - RFNC-VNIIEF, Sarov
4. FSBUN SSC “Institute of Biomedical Problems” of the Russian Academy of Sciences, Moscow
5. ZAO Biocad, Petrovo Village, Krasnogorsky District, Moscow Region
6. JSC "Generium", pos. Volginsky, Vladimir region.
7. Federal State Autonomous Educational Institution of Higher Education "Kazan (Volga Region) Federal University", Kazan
8. GBUZ "Research Institute - Regional Clinical Hospital №1
behalf of Professor S.V. Ochapovski ", Krasnodar
9. Federal Research Center for Research and Development of Immunobiological Preparations named after MP Chumakov, Russian Academy of Sciences, Moscow
Integration into the global scientific community
9. Participation in large international consortia (for example - CERN, JINR, FAIR, DESY, ISS and others) in the period from 2013 to 2015
Information not provided
10. Inclusion of field experiences of the organization in the Russian and international research networks. Is filled by organizations that have chosen reference group number 29 "Plant Technology"
Information not provided
11. Availability of foreign grants, international research programs or projects for the period from 2013 to 2015
The "Agreement on cooperation in basic biomedical research" was concluded with the University Clinic for Cardiothoracic Transplantation and Vascular Surgery of the Hannover Medical School for the period 2013-2018. In 2013-2015, studies were carried out on subcutaneous xenotransplantation of the valves of the heart of a pig to hamadryas baboons . Encouraging results have been obtained, research is ongoing.
SCIENTIFIC POTENTIAL OF THE ORGANIZATION
The most significant results of basic research
12. Scientific areas of research conducted by the organization, and the most significant results obtained in the period from 2013 to 2015
Number 67.Study of the mechanisms of psycho-emotional stress and resistance to it.
Studies have been conducted to investigate the nature of age related and individual characteristics of the regulation of the hypothalamic-pituitary adrenal system (GGAS) according to the mechanism of negative feedback. 10 young (6-9 years) and 10 old (20-29 years) animals of different psycho-physiological type (standard, control - SB; depressive-like and restless - DAB) after their adaptation to the living conditions in individual metabolic cells were administered intramuscularly dexamethasone in a dose 0.5 mg / kg at 22.00 h - the period of minimal activity of GGAS and, as expected, the greatest sensitivity of GGAS to stimuli). A similar pattern of corticosteroid concentrations was found in young and old animals, regardless of their belonging to a psychophysiological type prior to drug administration, 12 and 18 hours later with maximum inhibition after 18 hours. Return to the original level of functioning of GGAS was age-dependent in its nature: in young animals, return to the initial level of functioning occurred after 36 hours, while in old animals at that time suppression of corticosteroid secretion persisted (p <0.001).
1. Individual differences in stress responsiveness of the hypothalamic- pituitary-adrenal axis and its vasopressinergic regulation in old monkeys.
ND Goncharova, VY Marenin, TE Oganyan. Journal of Behavioral and Brain Science 5 (7), 280-294, 2015
2. Age-specific and individual features of vasopressinergic regulation of the Hypothalamic-pituitary-Adrenal system in Primates
ND Goncharova, TE Oganyan, VY Marenin, AA Vengerin. Bulletin of experimental biology and medicine 158 (6), 804-806, 2015
3. Correction of impaired glucose tolerance using tetrapeptide pancragen in old female rhesus monkeys
ND Goncharova, LG Ivanova, TE Oganyan, AA Vengerin, VK Khavinson. Adv. geront. 28 (3), 579-585, 2015
4. AGE-related and individual characteristics of vasopressinergic regulation of the hypothalamo-pituitary adrenal system in primates
Goncharova N.D., Oganyan T.E., Marenin V.Yu., Vengerin A.A. Bulletin of experimental biology and medicine. 2014. T. 158. No. 12. P. 773-776.
5. Age-related disturbances of the hypothalamo-pituitary adrenal system: experimental research on primates.
Goncharova N.D. Successes of gerontology. 2014. Vol. 27. No. 2. P. 269-274.
№ 75. Development of standardized biomodels in laboratory animals.
Eighteen biochemical parameters of blood sera of males of cynomolgus monkeys of different rank generally correspond to the values characteristic for macaques. For all the analyzed serum biochemical parameters, there are no significant differences between high-ranking and low-ranking animals . It shows a comparable level of clinical state of different rank monkeys.
High-ranking individuals demonstrate a high level of ability to solve tests on spatial orientation, an average level of ability to learn, and, on average, a low level of research activity. At the same time, individual differences are most pronounced when performing tests for exploratory activity or tests related to spatial orientation and ability to learning high-ranking animals could be divided into fairly homogeneous groups. Individuals of the low-ranking group show very ambiguous results. In animals of this category individual differences are more pronounced.
The aggressiveness of males is closely related to their dominance. The direct form of implementation of the hierarchical claims of male rhesus macaques is a demonstration of aggressiveness. The aggressiveness of males is not a quality that determines their anxiety. However, high anxiety, with a high probability, is associated with high aggressiveness. By their temper, males of rhesus monkeys can be divided into two categories: males with an active temper and males with a passive temper. Males with an active temper have a significantly higher motor activity, aggressiveness, and lower sociability and depression. Males with a passive temper are divided into two subcategories: passive confident (high-ranking males) and passive insecure (low-ranking).
1.THE ABILITY OF ADOLESCENT HAMADRYAS BABOONS (PAPIO HAMADRYAS) TO SOLVE A MODIFIED PIAGET A-NOT-B ERROR TEST
Anikaev A.E., Chalyan V.G., Meishvili N.V. Neuroscience and Behavioral Physiology. 2015. 2. RESEARCH OF ABILITIES OF HAMADRYAS BABOONS (PAPIO HAMADRYAS) TO SOLVING TASKS ON SUBJECT MANIPULATION
Anikaev A.E., Chalyan V.G., Meishvili N.V. Bulletin of experimental biology and medicine. 2015. V. 159. № 1. S. 95-97.
3. RELATIONS BETWEEN MALES AND INFANTS WITH IN MACQUES AND BABOONS (COMPARATIVE STUDY)
Y. Lipina, N.V. Meishvili, V.G. Chalyan Bulletin of Moscow University. Series 23: Anthropology. 2014. № 2. S. 99-108.
4. ABILITY OF ADOLESCENT HAMADRYAS BABOONS (PAPIO HAMADRYAS) TO SOLVING THE MODIFIED TASK OF THE PAYAGE “A-NOT-B ERROR”
Anikaev A.E., Chalyan V.G., Meishvili N.V. Russian physiological journal named after I.M. Sechenov. 2014. T. 100. No. 4. P. 394-405.
Number 81. Development of new cellular technologies.
The experimental myocardial infarction was reproduced on hamadryas baboons by bandaging at the border of the middle and upper third of the coronary and anterior descending artery. Myocardial infarction was confirmed by ECG and biochemical tests. Introduction of allogenic mesenchymal stem cells (MSCs) at the rate of 2 million / kg of weight during the first day of the infusion resulted in 3 years of observation of vascularization and capillarization of the myocardial infarction zone, detected in histological sections, unlike the control animals (not received MSC), in which the growth of coarse fibrous connective tissue was determined in the infarction area.
The bank of cryconserved cells was replenished with a new depositor — a culture of human cardiomyocytes (CSK-O), obtained as a result of the differentiation of human stem cells after exposure to the 5-azacytidine differentiating agent.
For therapeutic purposes, stem cell culture fluid (QOL) was used. Skin lesions, deep necrosis on the surface of the body treated with QOL led to wound cleansing, the formation of granulations and, ultimately, to healing with slightly noticeable depigmentation sites that occurred much faster than with the use of classical medical preparations.
1. Cellular immunity standard values in Macaca fascicularis. Ignatova IE, Agrba VZ, Karal- Ogly DD.
Bull Exp Biol Med. 2014 Jun; 157 (2): 265-7. doi: 10.1007 / s10517-014-2541-x. ,Epub 2014
Jun 24.
2. Physiological parameters of Macaca fascicularis immunized with anti-rubella vaccine with germanium-based adjuvants.
Karal-Ogly DD, Agrba VZ, Lavrent'eva IN, Ambrosov IV, Matelo SK, Chuguev YP, Gvaramiya IA, Gvozdik TE, Mukhametzyanova EI.
Bull Exp Biol Med. 2014 May; 157 (1): 81-4. doi: 10.1007 / s10517-014-2497-x. Epub 2014
Jun 10.
3. RESEARCH OF THE BIOLOGICAL SAFETY OF THE INCRETE OF VITALY IMPORTANT PARENCHIMATOUS ORGANS OBTAINED AS A RESULT OF ISOLATED EXTRACORPORAL PERFUSION OF XENOGENIC BIO MATERIAL. Agrba V.Z., Lubyako A.A., Araviashvili D.E., Coral-Ogly D.D., Chuguev Yu.P., Ignatova I.E., Sergeeva N.V., Gvaramiya I.A., Rusia A.G., Budanov R.V. Bioprotection and biosafety. 2013. Vol. 5. No. 1 (14). Pp. 44-58.
4. TRANSPLANTATION OF MESENCHEMAL STEM CELLS OF PRIMATES TO MONKEYS WITH EXPERIMENTALLY INDUCED MI-CARD INFARCT
Agrba V.Z., Porkhanov V.A., Karal-ogly D.D., Leontyuk A.V., Kovalenko A.L., Sholin I.Yu., Gvozdi
4. TRANSPLANTATION OF MESENCHEMAL STEM CELLS OF PRIMATS TO MONKEYS WITH EXPERIMENTALLY INDUCED MI-CARD INFARCT
Agrba V.Z., Porkhanov V.A., Karal-ogly D.D., Leontyuk A.V., Kovalenko A.L., Sholin I.Yu., Gvozdik T.E., Ignatova I.E., Agumava A.A., Chuguev Yu.P., Gvaramiya I.A., Lapin B.A. Cell technology in biology and medicine. 2015. No. 4. P. 286-288.
№ 119. Molecular epidemiology, ecology of infectious agents
During the massive outbreak of infectious myocarditis, among the hamadryas baboons the Mengo-like virus strain 3761 UTI (family Picornaviridae, genus Cardiovirus) was isolated from a dead animal. A full-length genome of the virus was identified. A real-time PCR test system was developed to detect RNA viruses of the genus Cardiovirus.
194 cultures of S.aureus, 6 - S.epidermidis, 3- S.intermedius, 1 - S.simulans, 1- S.haemolyticus, 1 - S.sciuri were isolated from monkeys. Oxacillin-resistant strains of staphylococci were shown to be more common in monkeys than in humans (20.7% and 5%, respectively). Vancomicin-resistant S.aureus strains isolated from monkeys were found in 6.3% of cases, while this antibiotic-resistant isolates of Staphylococcus aureus from humans were not noted. All cultures of S.aureus exhibit high sensitivity to antimicrobial agents of various groups. Based on the group of the group of strains of lotus staphylococcus, which included, first of all, isolates from pneumonia, intestinal infection, pus in various biomaterials, the structural polymorphism of the variable region of the coagulase gene was studied by PCR-RFLP. The vast majority of isolates from monkeys, , belonged to 2 groups of the coagulase gene - the 4th and 12th according to the type of restriction.
Hepatitis A virus (HAV) has been identified, which caused HAV infection in green monkeys imported from natural habitats (Tanzania). In monkeys all specific laboratory markers characteristic of hepatitis A were detected: anti-HAV IgM, anti-HAV IgG, Ag HAV, and HAV RNA. The cause of the infection was the HAV V genotype belonging to strains of monkey origin which was confirmed by sequencing and phylogenetic analysis.
1. Lapin BA, Yakovleva LA. Spontaneous and experimental malignancies in non-human primates. J Med Primatol. 2014 Apr; 43 (2): 100-10. doi: 10.1111 / jmp.12098. Epub 2014 Jan 7.
2. Historical Outbreaks of Simon Hemorrhagic Fever in Cavity Macaques Were Caused by Distinct Arteriviruses.
Lauck M, Alkhovsky SV, Bào Y, Bailey AL, Shevtsova ZV, Shchetinin AM, Vishnevskaya TV, Lackemeyer MG, Postnikova E, Mazur S, Wada J, Radoshitzky SR, Friedrich TC, Lapin BA, Deriabin PG, Jahrling PB, Goldberg TL , O'Connor DH, Kuhn JH. J Virol. 2015 Aug; 89 (15): 8082-7. doi: 10.1128 / JVI.01046-15.
3. STUDY OF A POSSIBLE ROLE OF CYTOMEGALOVIRUS INFECTION IN THE DEATH AND EARLY NEONATAL MORTALITY OF INFANTS OF ADLER COLONY. Shamsutdinova O.A., Agumava A.A., Chikobava M.G., Vyshemirsky O.I.
Bulletin of experimental biology and medicine. 2015. V. 160. № 7. S. 101-103.
4. SENSITIVITY TO ANTIBACTERIAL DRUGS
STAPHYLOCOCCUS AUREUS FROM MONKEYS. Kalashnikov V.A.
Bulletin of veterinary medicine. 2015. № 4 (75). Pp. 35-39.
5. RF patent “Method for PCR analysis of a biological object, a device for its implementation and composition included in the device” No. RU 2012140241 dated 03/27/2014
13. Protected dissertations prepared for the period from 2013 to 2015 based on field experimental work of the institution. It is filled in by organizations that have chosen reference group No. 29 “Plant growing technologies”.
Information not provided
14. The list of the most significant publications and monographs prepared
employees of the scientific organization for the period from 2013 to 2015
Publications.
1. An enzootic outbreak of disease associated with pathogenic E. coli in Adler monkey colony.
Lapin BA, Yakovleva LA, Dzhikidze EK, Gvozdik TE, Agumava AA, Stasilevich ZK, Danilova IG.
J Med Primatol. 2015 Dec; 44 (6): 355-63. doi: 10.1111 / jmp.12184. Epub 2015 Jul 27. Impact factor 0.93, Scientific Citation Systems Web of Sci, PubMed
2. Historical Outbreaks of Simon Hemorrhagic Fever in Cavity Macaques Were Caused by Distinct Arteriviruses.
Lauck M, Alkhovsky SV, Bào Y, Bailey AL, Shevtsova ZV, Shchetinin AM, Vishnevskaya TV, Lackemeyer MG, Postnikova E, Mazur S, Wada J, Radoshitzky SR, Friedrich TC, Lapin BA, Deriabin PG, Jahrling PB, Goldberg TL , O'Connor DH, Kuhn JH.
J Virol. 2015 Aug; 89 (15): 8082-7. doi: 10.1128 / JVI.01046-15. Epub 2015 May 13.
Impact factor 4,606, Web of Sci, Scientific Citation Systems, PubMed
3. Spontaneous and experimental malignancies in non-human primates. Lapin BA, Yakovleva LA.
J Med Primatol. 2014 Apr; 43 (2): 100-10. doi: 10.1111 / jmp.12098. Epub 2014 Jan 7. Review. Impact factor 0.93, Scientific Citation Systems Web of Sci, PubMed
4. Cellular immunity standard values in Macaca fascicularis. Ignatova IE, Agrba VZ, Karal-Ogly DD.
Bull Exp Biol Med. 2014 Jun; 157 (2): 265-7. doi: 10.1007 / s10517-014-2541-x. Epub 2014
5. Age-specific and individual features of vasopressinergic regulation of the hypothalamic-pituitary-adrenal system in primates.
Goncharova ND, Oganyan TE, Marenin VY, Vengerin AA.
Bull Exp Biol Med. 2015 Apr; 158 (6): 804-6. doi: 10.1007 / s10517-015-2866-0. Epub 2015
Apr 21.
Impact factor 0.448, Web of Sci, Scientific Citation Systems, PubMed
6. Study of Hamadryas Baboons (Papio Hamadryas) Ability to Solve Object Manipulation Tasks.
Anikaev AE, Chalyan VG, Meishvili NV.
Bull Exp Biol Med. 2015 May; 159 (1): 85-6. doi: 10.1007 / s10517-015-2896-7. Epub 2015
Jun 3.
Impact factor 0.448, Web of Sci, Scientific Citation Systems, PubMed
7. Role of anaerobic bacteria in simian enteric diseases. Stasilevich ZK, Dzhikidze EK, Kalashnikova VA, Sultanova OA.
Bull Exp Biol Med. 2013 Dec; 156 (2): 248-51. DOI: 10.1007 / s10517-013-2323-x
Impact factor 0.448, Web of Sci, Scientific Citation Systems, Pub Med
8. Potential Contribution of the Prenatal and Early Neonatal Mortality of Monkeys in the Adler Breeding Center.
Shamsutdinova OA, Agumava AA, Chikobava MG, Vyshemirsky OI.
Bull Exp Biol Med. 2015 Nov; 160 (1): 88-90. doi: 10.1007 / s10517-015-3105-4. Epub 2015
Nov 25.
Impact factor 0.448, Web of Sci, Scientific Citation Systems, PubMed
9. Analysis of the patient-reported outcomes from the LUME-Lung 1 trial: a randomized, double-blind, placebo-controlled study.
Novello S, Kaiser R, Mellemgaard A, Douillard JY, Orlov S, Krzakowski M, Von Pawel J, Gottfried M, Bondarenko I, Liao M, Barrueco J, Gaschler-Markefski B, Griebsch I, Palmer M, Reck M; LUME-Lung 1 Study Group ..
Eur J Cancer. 2015 Feb; 51 (3): 317-26. doi: 10.1016 / j.ejca.2014.11.015. Epub 2014 Dec 17.
Impact factor 6,163, Web of Sci, Scientific Citation Systems, PubMed
10. Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomized, phase 3 trials.
Yang JC, Wu YL, Schuler M, Sebastian M, Popat S, Yamamoto N, Zhou C, Hu CP, O'Byrne K, Feng J, Lu S, Huang Y, Geater SL, Lee KY, Tsai CM, Gorbunova V, Hirsh V, Bennoun J, Orlov S, Mok T, Boyer M, Su WC, Lee KH, Kato T, Massey D, Shahidi M, Zazulina V, Sequist LV.
Lancet Oncol. 2015 Feb; 16 (2): 141-51. doi: 10.1016 / S1470-2045 (14) 71173-8. Epub 2015
Jan 12.
Impact factor 26,509, Web of Sci Scientific Citation Systems, PubMed Monographs.
1. Vladimir S. Saakov, Alexander I. Krivchenko, Eugene Rozengardt, Irina G. Danilova. "Derivative Spectrophotometry and PAM-Fluorescence in Corporative Biochemistry". Springer International Publishing AG Switzerland, 2015, 611 p. ISBN 978-3-319-11595-5, ISBN 978-3- 319-11596-2 (eBook), DOI 10.1007 / 978-3-319-11596-2
15. Grants for basic research implemented with the support of the Russian Foundation for Basic Research, the Russian Humanitarian Scientific Foundation, the Russian Scientific Foundation and others
1. RFBR project No. 15-04-07896-a “Development of biomarkers of increased vulnerability to stress and accelerated aging based on studying the characteristics of vasopressinergic regulation of the stress-reactivity of GGAS in laboratory primates differing in the type of adaptive behavior”.
Duration 2015-2017 General financing 1.600.000,00 rub.
2. RFBR project No. 15-04-05283-a "Study of the ability to learning in lower monkeys of different age group ."
Duration 2015-2017 Total financing 1.425.000,00 rub.
16. Grants implemented on the basis of the organization's field experience with the support of Russian and International scientific foundations. It is filled in by organizations that have chosen reference group No. 29 “Crop technology”.
Information not provided
INNOVATIVE POTENTIAL OF SCIENTIFIC ORGANIZATION
The most significant results of exploratory and applied research
17. Exploratory and applied projects implemented within the framework of federal targeted programs, as well as with the support of development funds from 2013 to 2015
Information not provided
Innovative potential of a scientific organization
18. Availability of technological infrastructure for applied research.
Information not provided
19. The list of the most significant developments of the organization, which were introduced for the period from 2013 to 2015
Information not provided
EXPERT AND CONTRACTING ACTIVITIES OF THE ORGANIZATION
Expert activities of scientific organizations
20. Preparation of normative-technical documents of international, interstate and national importance, including standards, norms, rules, technical regulations and other regulatory documents approved by federal executive bodies, international and intergovernmental bodies
Information not provided
Doing research and services for other organizations
21. List of the most significant research, developmental and technological works and services performed under contracts for the period from 2013 to 2015
1. “Work on the preparation of primates for subsequent preclinical studies of promising vaccines against particularly dangerous viral diseases”. Customer FGBU "FNITSEM them. N.F. Gamalei "of the Ministry of Health of Russia, 2015.
2. "Conducting a preclinical study to investigate a comparative toxicity of the Rituximab bioassay drug (Mabsiens SA) with repeated administration in comparison with the reference drug Mabthera (F. Hoffmann-La Rosh) and the intact group" Customer Nanolek LLC , year 2014.
3. " Study of chronic toxicity and pharmacokinetics of the drug CON-2302 in monkeys", the customer of CJSC Research Institute of Chemical Diversity, 2014.
4. "Preclinical study of toxicity and pharmacokinetics with a single intravenous administration of BCD-100 on cynomolgus monkeys (Macaca fascicularis)", the customer of ZAO "Biocad". 2015
5. “Preclinical toxicity study with repeated intravenous administration of BCD-100 for 13 weeks followed by a 13-week recovery period on cynomolgus monkeys (Macaca fascicularis), performed in accordance with the GLP Good Laboratory Practice Standard”, the customer is Biocad CJSC. 2015
6. “Comparative toxicity with repeated subcutaneous administration and local irritating action on Javanese macaques (Macaca fascicularis) of Adalimumab (FARMAPARK LLC, Russia) and Humira reference drug (VetterPharma, Germany), customer Biocad CJSC. 2015
7. " Study of anti-inflammatory activity with repeated subcutaneous injection of biospecific monoclonal antibodies against interleukin 17 and tumor necrosis factor alpha BCD-121 to Javanese monkeys (Macaca fascicularis) for 42 days on a collagen-induced arthritis model", customer of Biocad. 2015
8. “ Study of the toxicity and basic pharmacokinetic parameters of the drug BCD-121 in a single subcutaneous injection to Javanese macaques (Macaca fascicularis)” customer Biocad. 2015
Other indicators of a leading position organizations in the relevant scientific direction
(submitted at the request of the organization in free form)
22.Other indicators showing the leading position of the organization of a
relevant scientific direction, and the information that the organization wants to present additionally
The Research Institute of Medical Primatology is a unique research Institution of the Russian Federation. Its colony contains about 5,000 monkeys of 20 species. Thus, the Institute of Medical Primatology is not
only the only primate center of Russia, but also the largest center in Europe.
Laboratory primates are essentially “laboratory counterparts” of man. The results of biomedical and biological experiments obtained on monkeys can be extrapolated to humans in fact without adjustment. The staff of the Institute employs highly qualified specialists who are skillful in large-scale maintenance and breeding of primates, and conducting biomedical experiments on them.
The demand for such experiments in the country is growing, as well as the number
of scientific areas in which the use of laboratory primates is needed.